Invitrogen
NeoMarkers, Lab Vision, Endogen, Pierce, BioSource International, Zymed Laboratories, Caltag, Molecular Probes, Research Genetics, Life Technologies, Applied Biosystems, GIBCO BRL, ABgene, Dynal, Affinity BioReagents, Nunc, Invitrogen, NatuTec, Oxoid, Richard-Allan Scientific, Arcturus, Perseptive Biosystems, Proxeon, eBioscience
antibody
CD2 Monoclonal Antibody (RPA-2.10), Functional Grade, eBioscience™
U2 - 10.1038/s41551-017-0029. DO - 10.1038/s41551-017-0029. JO - Nature Biomedical Engineering. JF - Nature Biomedical Engineering. B-1 B cells (Aziz et al. The role of FO and MZ B cells collectively known as B-2 cells in the early immune response and inflammatory cytokine production during sepsis has been demonstrated previously (Kelly-Scumpia et al. 2011; Honda et al. B-1 cells comprising a minor portion of the total B cells in mice display unique. Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3 gene. PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor, IRS1 and Retinoblastoma protein. Pill with imprint G 0029 75 is White, Round and has been identified as Diclofenac Sodium and Misoprostol 75 mg / 200 mcg. It is supplied by Greenstone LLC. It is supplied by Greenstone LLC. Diclofenac/misoprostol is used in the treatment of osteoarthritis; rheumatoid arthritis and belongs to the drug class Nonsteroidal anti-inflammatory drugs.
16-0029-85
500µg
US 356
Benq Lcd Monitor Et-0029-b
monoclonal
mouse
nonconjugated
RPA-2.10
crab eating macaque, baboon , human, mouse, chimpanzee, pigs , rhesus macaque
immunohistochemistry, neutralization, flow cytometry
Published Application/Species/Sample/Dilution | Reference |
---|---|
| Venkatasubramanian S, Tripathi D, Tucker T, Paidipally P, Cheekatla S, Welch E, et al. Tissue factor expression by myeloid cells contributes to protective immune response against Mycobacterium tuberculosis infection. Eur J Immunol. 2016;46:464-79 pubmed publisher |
| Okoye Okafor U, Bartholdy B, Cartier J, Gao E, Pietrak B, Rendina A, et al. New IDH1 mutant inhibitors for treatment of acute myeloid leukemia. Nat Chem Biol. 2015;11:878-86 pubmed publisher |
| Grieco A, Billett H, Green N, Driscoll M, Bouhassira E. Variation in Gamma-Globin Expression before and after Induction with Hydroxyurea Associated with BCL11A, KLF1 and TAL1. PLoS ONE. 2015;10:e0129431 pubmed publisher |
| Wilson E, Singh A, Hullsiek K, Gibson D, Henry W, Lichtenstein K, et al. Monocyte-activation phenotypes are associated with biomarkers of inflammation and coagulation in chronic HIV infection. J Infect Dis. 2014;210:1396-406 pubmed publisher |
| Sereti I, Estes J, Thompson W, Morcock D, Fischl M, Croughs T, et al. Decreases in colonic and systemic inflammation in chronic HIV infection after IL-7 administration. PLoS Pathog. 2014;10:e1003890 pubmed publisher |
| Timblin G, Schlissel M. Ebf1 and c-Myb repress rag transcription downstream of Stat5 during early B cell development. J Immunol. 2013;191:4676-87 pubmed publisher |
| Liang H, Reinhardt R, Bando J, Sullivan B, Ho I, Locksley R. Divergent expression patterns of IL-4 and IL-13 define unique functions in allergic immunity. Nat Immunol. 2011;13:58-66 pubmed publisher |
| Park C, Majeti R, Weissman I. In vivo evaluation of human hematopoiesis through xenotransplantation of purified hematopoietic stem cells from umbilical cord blood. Nat Protoc. 2008;3:1932-40 pubmed publisher |
Lim S, Kim J, Jeon S, Shin M, Kwon J, Kim T, et al. Defective Localization With Impaired Tumor Cytotoxicity Contributes to the Immune Escape of NK Cells in Pancreatic Cancer Patients. Front Immunol. 2019;10:496 pubmed publisher | |
Cho J, Xu Z, Parthasarathy U, Drashansky T, Helm E, Zuniga A, et al. Hectd3 promotes pathogenic Th17 lineage through Stat3 activation and Malt1 signaling in neuroinflammation. Nat Commun. 2019;10:701 pubmed publisher | |
Denton A, Innocentin S, Carr E, Bradford B, Lafouresse F, Mabbott N, et al. Type I interferon induces CXCL13 to support ectopic germinal center formation. J Exp Med. 2019;216:621-637 pubmed publisher | |
Seeholzer T, Kurz S, Schlauderer F, Woods S, Gehring T, Widmann S, et al. BCL10-CARD11 Fusion Mimics an Active CARD11 Seed That Triggers Constitutive BCL10 Oligomerization and Lymphocyte Activation. Front Immunol. 2018;9:2695 pubmed publisher | |
Baumgartner C, Toifl S, Farlik M, Halbritter F, Scheicher R, Fischer I, et al. An ERK-Dependent Feedback Mechanism Prevents Hematopoietic Stem Cell Exhaustion. Cell Stem Cell. 2018;22:879-892.e6 pubmed publisher | |
Kostrzewski T, Borg A, Meng Y, Filipovic I, Male V, Wack A, et al. Multiple Levels of Control Determine How E4bp4/Nfil3 Regulates NK Cell Development. J Immunol. 2018;200:1370-1381 pubmed publisher | |
Wang Y, Ma C, Ling Y, Bousfiha A, Camcioglu Y, Jacquot S, et al. Dual T cell- and B cell-intrinsic deficiency in humans with biallelic RLTPR mutations. J Exp Med. 2016;213:2413-2435 pubmed | |
Lim S, Kim T, Lee J, Sonn C, Kim K, Kim J, et al. Ex vivo expansion of highly cytotoxic human NK cells by cocultivation with irradiated tumor cells for adoptive immunotherapy. Cancer Res. 2013;73:2598-607 pubmed publisher | |
Kap Y, van Meurs M, van Driel N, Koopman G, Melief M, Brok H, et al. A monoclonal antibody selection for immunohistochemical examination of lymphoid tissues from non-human primates. J Histochem Cytochem. 2009;57:1159-67 pubmed publisher | |
Schierloh P, Yokobori N, Aleman M, Landoni V, Geffner L, Musella R, et al. Mycobacterium tuberculosis-induced gamma interferon production by natural killer cells requires cross talk with antigen-presenting cells involving Toll-like receptors 2 and 4 and the mannose receptor in tuberculous pleurisy. Infect Immun. 2007;75:5325-37 pubmed |
Antibody
CD2 Monoclonal Antibody (RPA-2.10), Functional Grade, eBioscience™
16-0029-85
500µg
US 356
Monoclonal
Affinity chromatography
Mouse
Baboon, Chimpanzee, Cynomolgus Monkey, Human, Non-human primate, Porcine, Rhesus Monkey
Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent
Baboon, Chimpanzee, Cynomolgus Monkey, Human, Non-human primate, Porcine, Rhesus Monkey
RPA-2.10
IgG1, kappa
4° C
CD2 (LFA-2) is a monomeric surface antigen (MW range 45-58 kDa) of the human T-lymphocyte lineage that is expressed on all peripheral blood T cells. CD2 is one of the earliest T-cell markers, being present on more than 95% of thymocytes and it is also found on some natural killer cells, but not on B lymphocytes. Monoclonal antibodies directed against CD2 inhibit the formation of rosettes with sheep erythrocytes, indicating that CD2 is the erythrocyte receptor or is closely associated with it. The interaction between CD2 and CD58 stabilizes adhesion between T cells and antigen presenting or target cells. Relatively low affinity of CD2 to CD58 (as measured in solution) is compensated within the two-dimensional cell-cell interface to provide tight adhesion. Moreover, T cell activation induces increased CD2 expression and its lateral mobility, making easier contact between CD2 and CD58. Subsequently, T cell activation causes fixation of CD58-CD2 at sites of cell-cell contact, thereby strengthening intercellular adhesion. CD2 deficiency reduces intestinal inflammation and helps to control infection. Diseases associated with CD2 dysfunction include penis squamous cell carcinoma and immune deficiency due to the absence of the thymus.
Et0021b7035a48
Liquid
Flow Cytometry: 0.5 µg/test, Functional assay: Assay-Dependent, Neutralization: Assay-Dependent
BOS_3050; Cd2; CD2 antigen; CD2 antigen (p50), sheep red blood cell receptor; CD2 molecule; CD2R; cluster of differentiation 2; Erythrocyte receptor; FLJ46032; LFA2; LFA-2; LFA-3 receptor; Ly37; Ly-37; Lymphocyte antigen 37; OX34; OX-34; OX-34 antigen; OX-45 surface antigen homolog to human T lymphocyte CD2 antigen; Rosette receptor; SRBC; T11; T-cell surface antigen CD2; T-cell surface antigen T11/Leu-5
Thermo Fisher Scientific
81 Wyman Street
Waltham, MA USA 02451
https://www.thermofisher.com81 Wyman Street
Waltham, MA USA 02451
headquarters: USA
PIK3R3 | |||||||||||||||||
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Aliases | PIK3R3, p55, p55-GAMMA, p55PIK, phosphoinositide-3-kinase regulatory subunit 3, PI3KR3 | ||||||||||||||||
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Species | Human | Mouse | |||||||||||||||
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Location (UCSC) | Chr 1: 46.04 – 46.13 Mb | Chr 4: 116.22 – 116.3 Mb | |||||||||||||||
PubMed search | [3] | [4] | |||||||||||||||
Wikidata | |||||||||||||||||
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Phosphatidylinositol 3-kinase regulatory subunit gamma is an enzyme, which in humans is encoded by the PIK3R3gene.[5][6]
Interactions[edit]
PIK3R3 has been shown to interact with Insulin-like growth factor 1 receptor,[7]IRS1[7][8] and Retinoblastoma protein.[9]
References[edit]
- ^ abcGRCh38: Ensembl release 89: ENSG00000117461 - Ensembl, May 2017
- ^ abcGRCm38: Ensembl release 89: ENSMUSG00000028698 - Ensembl, May 2017
- ^'Human PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^'Mouse PubMed Reference:'. National Center for Biotechnology Information, U.S. National Library of Medicine.
- ^Dey BR, Furlanetto RW, Nissley SP (May 1998). 'Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor'. Gene. 209 (1–2): 175–83. doi:10.1016/S0378-1119(98)00045-6. PMID9524259.
- ^'Entrez Gene: PIK3R3 phosphoinositide-3-kinase, regulatory subunit 3 (p55, gamma)'.
- ^ abMothe, I; Delahaye L; Filloux C; Pons S; White M F; Van Obberghen E (Dec 1997). 'Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins'. Mol. Endocrinol. 11 (13): 1911–23. doi:10.1210/mend.11.13.0029. ISSN0888-8809. PMID9415396.
- ^Xia, X; Serrero G (Aug 1999). 'Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation'. Biochem. J. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. ISSN0264-6021. PMC1220424. PMID10417350.
- ^Xia, Xianmin; Cheng Aiwu; Akinmade Damilola; Hamburger Anne W (Mar 2003). 'The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest'. Mol. Cell. Biol. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. ISSN0270-7306. PMC151709. PMID12588990.
Further reading[edit]
- Pons S, Asano T, Glasheen E, et al. (1995). 'The structure and function of p55PIK reveal a new regulatory subunit for phosphatidylinositol 3-kinase'. Mol. Cell. Biol. 15 (8): 4453–65. doi:10.1128/MCB.15.8.4453. PMC230685. PMID7542745.
- Andersson B, Wentland MA, Ricafrente JY, et al. (1996). 'A 'double adaptor' method for improved shotgun library construction'. Anal. Biochem. 236 (1): 107–13. doi:10.1006/abio.1996.0138. PMID8619474.
- Tuscano JM, Engel P, Tedder TF, et al. (1996). 'Involvement of p72syk kinase, p53/56lyn kinase and phosphatidyl inositol-3 kinase in signal transduction via the human B lymphocyte antigen CD22'. Eur. J. Immunol. 26 (6): 1246–52. doi:10.1002/eji.1830260610. PMID8647200.
- Takahashi-Tezuka M, Hibi M, Fujitani Y, et al. (1997). 'Tec tyrosine kinase links the cytokine receptors to PI-3 kinase probably through JAK'. Oncogene. 14 (19): 2273–82. doi:10.1038/sj.onc.1201071. PMID9178903.
- Mothe I, Delahaye L, Filloux C, et al. (1998). 'Interaction of wild type and dominant-negative p55PIK regulatory subunit of phosphatidylinositol 3-kinase with insulin-like growth factor-1 signaling proteins'. Mol. Endocrinol. 11 (13): 1911–23. doi:10.1210/mend.11.13.0029. PMID9415396.
- Xia X, Serrero G (1999). 'Multiple forms of p55PIK, a regulatory subunit of phosphoinositide 3-kinase, are generated by alternative initiation of translation'. Biochem. J. 341 (3): 831–7. doi:10.1042/0264-6021:3410831. PMC1220424. PMID10417350.
- Inukai K, Funaki M, Anai M, et al. (2001). 'Five isoforms of the phosphatidylinositol 3-kinase regulatory subunit exhibit different associations with receptor tyrosine kinases and their tyrosine phosphorylations'. FEBS Lett. 490 (1–2): 32–8. doi:10.1016/S0014-5793(01)02132-9. PMID11172806.
- Hafizi S, Alindri F, Karlsson R, Dahlbäck B (2003). 'Interaction of Axl receptor tyrosine kinase with C1-TEN, a novel C1 domain-containing protein with homology to tensin'. Biochem. Biophys. Res. Commun. 299 (5): 793–800. doi:10.1016/S0006-291X(02)02718-3. PMID12470648.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). 'Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences'. Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC139241. PMID12477932.
- Xia X, Cheng A, Akinmade D, Hamburger AW (2003). 'The N-Terminal 24 Amino Acids of the p55 Gamma Regulatory Subunit of Phosphoinositide 3-Kinase Binds Rb and Induces Cell Cycle Arrest'. Mol. Cell. Biol. 23 (5): 1717–25. doi:10.1128/MCB.23.5.1717-1725.2003. PMC151709. PMID12588990.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). 'Complete sequencing and characterization of 21,243 full-length human cDNAs'. Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID14702039.
- Rual JF, Venkatesan K, Hao T, et al. (2005). 'Towards a proteome-scale map of the human protein-protein interaction network'. Nature. 437 (7062): 1173–8. Bibcode:2005Natur.437.1173R. doi:10.1038/nature04209. PMID16189514.
- Soroceanu L, Kharbanda S, Chen R, et al. (2007). 'Identification of IGF2 signaling through phosphoinositide-3-kinase regulatory subunit 3 as a growth-promoting axis in glioblastoma'. Proc. Natl. Acad. Sci. U.S.A. 104 (9): 3466–71. Bibcode:2007PNAS..104.3466S. doi:10.1073/pnas.0611271104. PMC1802005. PMID17360667.
- Kallin A, Johannessen LE, Cani PD, et al. (2007). 'SREBP-1 regulates the expression of heme oxygenase 1 and the phosphatidylinositol-3 kinase regulatory subunit p55 gamma'. J. Lipid Res. 48 (7): 1628–36. doi:10.1194/jlr.M700136-JLR200. PMID17452746.
Et0021b78223f3
Et 0029 Belgique
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